Nicotinamide riboside chloride: authorised novel food in the EU

Conditions of use and maximum levels

Table 1, column "Conditions under which the novel food may be used", as written:

• Food supplements as defined in Directive 2002/46/EC: 300 mg/day for the adult population, excluding pregnant and lactating women 230 mg/day for pregnant and lactating women
• Foods for special medical purposes as defined by Regulation (EU) No 609/2013 for the adult population, excluding pregnant and lactating women: In accordance with the particular nutritional requirements of the persons for whom the products are intended
• Total diet replacement for weight control as defined by Regulation (EU) No 609/2013 for the adult population, excluding pregnant and lactating women: 500 mg/day
• Meal replacements for the adult population, excluding pregnant and lactating women: 150 mg/meal (maximum 2 meals/day up to a maximum of 300 mg/day)

Additional specific labelling requirements

For Food supplements as defined in Directive 2002/46/EC: The designation of the novel food on the labelling of the foodstuffs containing it shall be ‘nicotinamide riboside chloride’.

For Foods for special medical purposes as defined by Regulation (EU) No 609/2013 for the adult population, excluding pregnant and lactating women; Total diet replacement for weight control as defined by Regulation (EU) No 609/2013 for the adult population, excluding pregnant and lactating women; Meal replacements for the adult population, excluding pregnant and lactating women: 1. The designation of the novel food on the labelling of the foodstuffs containing it shall be ‘nicotinamide riboside chloride’ 2. The labelling of foodstuffs containing the novel food shall bear a statement that those foods should only be consumed by persons above 18 years of age excluding pregnant and lactating women.

Specification (Table 2)

Table 2 of the Annex, row with the same name, as written:

Description/Definition:

The novel food is a synthetic form of nicotinamide riboside. The novel food contains ≥ 90 % nicotinamide riboside chloride, predominantly in its β form, the remaining components being residual solvents, reaction by-products and degradation products.

Nicotinamide riboside chloride:

CAS number: 23111-00-4

EC number: 807-820-5

IUPAC name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyridin-1-ium-3-carboxamide;chloride

Chemical formula: C11H15N2O5Cl

Molecular weight: 290,7 g/mol

Characteristics/Composition:

Colour: White to light brown

Form: Powder

Identification: Conforms by NMR (nuclear magnetic resonance)

Nicotinamide riboside chloride: ≥ 90 %

Water content: ≤ 2 %

Residual solvents:

Acetone: ≤ 5 000 mg/kg

Methanol: ≤ 1 000 mg/kg

Acetonitrile: ≤ 50 mg/kg

Methyl tert-butyl ether: ≤ 500 mg/kg

Reaction by-products:

Methyl acetate: ≤ 1 000 mg/kg

Acetamide: ≤ 27 mg/kg

Acetic acid: ≤ 5 000 mg/kg

Heavy metals:

Arsenic: ≤ 1 mg/kg

Mercury*: ≤ 0,1 mg/kg

Cadmium*: ≤ 1 mg/kg

Lead*: ≤ 0,5 mg/kg

Microbiological criteria:

Total Plate Count: ≤ 1 000 CFU/g

Yeast and Mould: ≤ 100 CFU/g

Escherichia coli: Absence in 10 g

CFU: colony forming units

(*) only for foods for special medical purposes, total diet replacement for weight control and meal replacements

Source and version

Implementing Regulation (EU) 2017/2470, Annex, Union list of novel foods, Table 1. Consolidated text of 10 August 2026. The text above is copied from that document without change except that amendment markers are removed. It is not advice and it does not decide whether a particular product is covered.

• Consolidated text on EUR-Lex

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